Lifestyle

Drug combination gets advanced liver cancer patients to surgery

A combination of the kinase-inhibitor drug cabozantinib and the immunotherapy drug nivolumab can make curative surgery possible in some liver cancer patients who would normally not be considered surgery candidates. Results published July 29 in the journal Nature Cancer by researchers at the Johns Hopkins Kimmel Cancer Center describe the benefits of this drug combination. […]

Lifestyle

Researchers ID location on brain protein linked to Parkinson’s disease development

Johns Hopkins Medicine researchers say they have pinpointed the section of alpha-synuclein, a protein in the brain that causes it to latch onto brain cells called neurons and likely drives the development of Parkinson’s disease, a progressively worsening disorder that disrupts movement and neurological functions. The findings may help scientists develop a treatment that curbs […]

Lifestyle

Mice treated with this cytokine lose weight by ‘sweating’ fat

Treating obese mice with the cytokine known as TSLP led to significant abdominal fat and weight loss compared to controls, according to new research published Thursday in Science from researchers in the Perelman School of Medicine at the University of Pennsylvania. Unexpectedly, the fat loss was not associated with decreased food intake or faster metabolism. […]

Lifestyle

Scientists discover a surprising new way that tuberculosis suppresses immunity

When Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, infects a person, the body’s immune response is critical to how the disease will progress—either helping the body fight the bacterium or exacerbating the infection University of Maryland researchers discovered a way that Mtb can cause a person’s immune cells to lower their defenses. Specifically, they […]

Lifestyle

Preventing childhood obesity requires changes in parents’ and clinicians’ early-life care

Rates of childhood obesity are at historically high levels in the U.S., yet there are few interventions that promote healthy weight gain in children from infancy to age two—a critical period for the development and prevention of childhood obesity. A new study published in Pediatrics found that fewer infants gained excess weight when low-income pregnant […]

Lifestyle

New versatile genetic test for lymphoid neoplasms supports personalized management of patients

Increasing knowledge about genomic biomarkers has facilitated better monitoring and personalized management of patients with B-cell malignant tumors. A new integrative, capture-based, next-generation sequencing (NGS) panel, LYmphoid NeXt-Generation Sequencing (LYNX), can detect and analyze standard and novel biomarkers in the most common lymphoid neoplasms simultaneously. This represents a crucial step towards more effective personalized treatment […]

Lifestyle

Five-year extended hormone therapy no better in breast cancer

Extending hormone therapy by five years does not provide benefit over a two-year extension among postmenopausal women with hormone receptor-positive breast cancer who had received five years of adjuvant endocrine therapy, according to a study published in the July 29 issue of the New England Journal of Medicine. Michael Gnant, M.D., from the Medical University […]